Untreated osteoporosis and higher FRAX as risk factors for tooth loss: a 5-year prospective study.

INTRODUCTION: Studies have shown that an impaired bone condition, represented by osteoporosis and increased fracture risk, may potentially aggravate periodontal disease and, consequently, the risk of tooth loss. This 5-year prospective study aimed to investigate whether systemic bone condition represents risk factor for tooth loss due to periodontal disease amongst elderly women. MATERIAL AND METHODS: Seventy-four participants, aged ≥ 65 years, who attended the 5-years recall for periodontal evaluation were involved. Baseline exposures were osteoporosis and fracture risk probabilities (FRAX). Women were grouped according to bone mineral density (BMD) and years of bone treatment for osteoporosis. The primary outcome at a 5-year follow-up was the number of tooth loss due to periodontal disease. Periodontitis staging and grading, and causes of tooth loss were recorded. RESULTS: The multivariate Poisson regression models showed that women with untreated/shortly treated osteoporosis were 4 times more likely to present higher number of tooth loss due to periodontal disease than those with normal BMD or treated for ≥ 3 years (risk ratio (RR) = 4.00, 95% CI 1.40-11.27). Higher FRAX was also linked to tooth loss (RR = 1.25, 95% CI 1.02-1.53). Receiver-operating characteristic (ROC) curve suggested that women with history of ≥ 1 tooth losses have higher chances of worse major FRAX (sensitivity = 72.2%; specificity = 72.2%). CONCLUSION: In this 5-year study, higher FRAX and untreated osteoporosis were risk factors for tooth loss. Women with normal BMD or treated for osteoporosis for ≥ 3 years did not show increased risk. Management of skeletal conditions should be emphasized with periodontal care for the prevention of tooth loss in elderly women.

Oral clinical findings and intensive care unit prognostic scores.

OBJECTIVE: Hospitalisation in intensive care unit (ICU) may cause changes in oral environment, which may influence patients' health status. The aim of this study was to evaluate the frequency of intraoral and extraoral findings observed during ICU admission, and to verify if there is an association with clinical prognosis scores. METHODS: Data regarding clinical characteristics of patients hospitalised in an ICU were collected from medical records. The prognostic scores Sepsis Related Organ Failure Assessment (SOFA) and Simplified Acute Physiology Score (SAPS 3) were estimated with data collected from admission and SOFA on the day of the oral examination as well. Data on oral mucosa lesions, saliva, dental condition and oral hygiene were evaluated during oral examinations. RESULTS: The association of oral findings with prognostic scores was statistically verified. The majority (92.2%) of the 170 evaluated patients showed extraoral or intraoral findings during ICU admission. The most frequent findings were chapped and crusted lips, coated tongue, pale mucosa, haemorrhagic lesions, candidiasis, depapillated tongue and traumatic lesions. There were significant higher prognostic scores in the presence of the following extraoral and intraoral findings: crusted and ulcerated lips, haemorrhagic lesions, jaundice, spontaneous oral bleeding, coated and depapillated tongue. Median SAPS 3 was higher in patients with poor oral hygiene. CONCLUSIONS: Oral findings were frequent in the population of patients hospitalised in the ICU and some of them were associated with worse prognostic scores. Routine oral examinations must be performed in hospitalised patients from ICUs for detection of oral markers of worse clinical prognosis.

Osteonecrosis of the jaws in patients under osteoporosis treatment: a nine-year experience report.

Objective: This study aimed to report the experience of medication-related osteonecrosis of the jaws (MRONJ) in osteoporotic patients for nine years, and their associated initiating factors. Materials and methods: The numbers of invasive oral procedures (IOP) (tooth extraction, dental implant placement, and periodontal procedures) and removable prostheses performed from January 2012 to January 2021 were obtained from the digital records of a large public dental center. There were an estimated 6,742 procedures performed in patients under osteoporosis treatment. Results: Two cases (0.03%) of MRONJ were registered in nine years amongst patients with osteoporosis who had dental treatment at the center. From the 1,568 tooth extractions, one patient (0.06%) developed MRONJ. There was also one case from the 2,139 removable prostheses delivered (0.05%). Conclusion: The prevalence of MRONJ associated with osteoporosis treatment was very low. The protocols adopted seem to be adequate for the prevention of this complication. The findings of this study reinforce the rare frequency of MRONJ associated with dental procedures in patients submitted to the pharmacological management of osteoporosis. An integral analysis of systemic risk factors and oral preventive strategies may be considered regularly in the dental treatment of these patients.

Osteonecrosis of the jaws in patients under osteoporosis treatment: a nine-year experience report

ABSTRACT Objective: This study aimed to report the experience of medication-related osteonecrosis of the jaws (MRONJ) in osteoporotic patients for nine years, and their associated initiating factors. Materials and methods: The numbers of invasive oral procedures (IOP) (tooth extraction, dental implant placement, and periodontal procedures) and removable prostheses performed from January 2012 to January 2021 were obtained from the digital records of a large public dental center. There were an estimated 6,742 procedures performed in patients under osteoporosis treatment. Results: Two cases (0.03%) of MRONJ were registered in nine years amongst patients with osteoporosis who had dental treatment at the center. From the 1,568 tooth extractions, one patient (0.06%) developed MRONJ. There was also one case from the 2,139 removable prostheses delivered (0.05%). Conclusions: The prevalence of MRONJ associated with osteoporosis treatment was very low. The protocols adopted seem to be adequate for the prevention of this complication. The findings of this study reinforce the rare frequency of MRONJ associated with dental procedures in patients submitted to the pharmacological management of osteoporosis. An integral analysis of systemic risk factors and oral preventive strategies may be considered regularly in the dental treatment of these patients.

The impact of oral hygiene instruction on plaque control in orthodontic patients: a cross-sectional study / O impacto da instrução de higiene oral no controle da placa bacteriana em pacientes ortodônticos: um estudo transversal

Objective: Deficient dental plaque control is common in adolescents, mainly among those wearing orthodontic apparatus. This study aimed to compare plaque control and oral hygiene habits in adolescents with and without fixed orthodontic appliances. Additionally, it was investigated whether personalized oral hygiene instruction (OHI) could be a predictor for reducing dental plaque accumulation in orthodontic patients. Material and Methods: Sixty-nine patients, aged 12 to 20 years, were evaluated in a public organization which provides dental care. A questionnaire of oral hygiene habits was applied, and the number of natural teeth and number of teeth with visible biofilm were obtained during clinical examination. A comparative analysis of sociodemographic and clinical data was performed, splitting this population into two groups: those who used fixed orthodontic appliances (n=40) and those who did not (n=29). Results: There were no differences in oral hygiene habits among groups. The Poisson regression showed that adolescents with fixed appliances were 54% more likely to have dental plaque buildup compared to those who did not. Among individuals wearing orthodontic appliance, those who had not received personalized OHI before or during orthodontic treatment were 78% more likely to have a greater number of teeth with bacterial plaque compared to instructed ones. Conclusion: Especially among the adolescents wearing fixed orthodontic appliances, those who have not received personalized OHI were almost twice as likely to have a greater number of teeth with dental biofilm accumulation. Dentists and dental hygienists play a prominent role in motivating and improving the quality of individual oral hygiene (AU)

Objetivo: O controle deficiente da placa dental é comum em adolescentes, principalmente entre aqueles que usam aparelhos ortodônticos. Este estudo teve como objetivo comparar o controle da placa e os hábitos de higiene oral em adolescentes com e sem aparelhos ortodônticos fixos. Além disso, foi investigado se a instrução de higiene oral (IHO) personalizada poderia ser um preditor para reduzir o acúmulo de placa dental em pacientes ortodônticos. Material e métodos: Sessenta e nove pacientes, de 12 a 20 anos, foram avaliados em uma organização pública que presta atendimento odontológico. Foi aplicado um questionário sobre hábitos de higiene oral, e o número de dentes naturais e o número de dentes com biofilme visível foram obtidos durante o exame clínico. Foi realizada uma análise comparativa dos dados sociodemográficos e clínicos, dividindo essa população em dois grupos: aqueles que usavam aparelhos ortodônticos fixos (n = 40) e aqueles que não o usavam (n = 29). Resultados: Não houve diferenças nos hábitos de higiene oral entre os grupos. A regressão de Poisson mostrou que os adolescentes que tinham aparelhos fixos apresentaram 54% mais chance de ter mais acúmulo de placa dental comparados aos que não tinham. Entre os indivíduos que usavam aparelhos ortodônticos, aqueles que não receberam IHO personalizada antes ou durante o tratamento ortodôntico apresentaram 78% mais chance de ter maior número de dentes com placa bacteriana em comparação com os que a receberam. Conclusão: Especialmente entre os adolescentes que usavam aparelhos ortodônticos fixos, aqueles que não receberam IHO personalizada tiveram quase duas vezes mais chances de ter um número maior de dentes com acúmulo de biofilme dental. Dentistas e higienistas dentais desempenham um papel proeminente na motivação e na melhoria da qualidade da higiene oral do indivíduo. (AU)

Factors Associated with Noncarious Cervical Lesions in Different Age Ranges: A Cross-sectional Study.

OBJECTIVES: Understanding the possible risk factors of noncarious cervical lesion (NCCL) is important for prevention and clinical management of the condition. The aim of this study was to investigate the factors associated with the prevalence of NCCL among adolescents, adults, and elderly people. MATERIALS AND METHODS: A cross-sectional study involving 501 participants aged 15 years or older was conducted. Participants were examined to assess the number of natural teeth and the prevalence and severity of NCCL by calibrated examiners. Data on age, gender, harmful toothbrushing habits, and acidogenic diet were collected through individual interviews. Multivariate Poisson's regression models were used to evaluate the association between the independent variables and the prevalence of NCCL according to the three age groups: 15 to 39, 40 to 64, and 65 years or older. RESULTS : The prevalence of NCCL among participants was 62.5% (95% confidence interval: 58.2-66.7). Among 15- to 39-year-old participants, the mean of NCCL was higher in males, those with lower number of teeth and acidogenic diet intake. Males aged 40 to 64 years and those with harmful brushing habits were more likely to present higher mean of NCCL. Elderly people with harmful toothbrushing habits had a greater mean of NCCL. CONCLUSION: Demographic (age and gender), clinical (number of teeth), and behavioral characteristics (harmful brushing habits and acidogenic diet) were meaningful factors associated with NCCL severity. The above-mentioned relationships varied between age groups.

Periodontal management of a patient with chronic kidney disease: a case report

The association between periodontal disease and chronic kidney disease (CKD) has been recognized over the years. Gingival overgrowth may be a side effect of some of the drugs prescribed for patients with CKD. Objective: The objective of this manuscript was to report the dental management of a patient with chronic renal disease who presented periodontitis and gingival overgrowth. Case report: A 55 years old male patient sought dental treatment, and was diagnosed with generalized periodontitis in advanced stage and gingival overgrowth. The overgrowth was associated to the use of amlodipine, a longacting calcium channel blocker. The treatment consisted of interruption of amlodipine, sessions of oral hygiene instruction and basic periodontal therapy. Thereafter, conventional periodontal therapy, with scaling and root planning of the four hemiarches, surgical periodontal therapy and gingivectomy of the overgrowth were performed. Considering periodontal sites with a probing depth (PD) > 4mm at baseline, mean PD was reduced (baseline: 5.94 ± 1.80; follow-up: 2.76 ± 1.38), as well as mean clinical attachment loss (baseline: 5.55 ± 1.51; followup: 4.52 ± 1.47). Periodontal disease was controlled and there was no recurrence of gingival overgrowth after 18 months of follow-up. Conclusion: The management of the reported patient with CKD and periodontal involvement included discontinuation of amlodipine, basic and advanced periodontal therapy and gingivectomy. Proper oral hygiene may help to prevent recurrence of the gingival overgrowth and to maintain periodontal health.

Introdução: A associação entre doença periodontal e doença renal crônica (DRC) tem sido reconhecida nos últimos anos. O crescimento gengival excessivo pode ser um efeito colateral de alguns medicamentos prescritos para pacientes com DRC. Objetivos: O objetivo deste estudo foi relatar o manejo odontológico de um paciente com DRC que apresentava periodontite e aumento gengival. Relato do caso: Um paciente do sexo masculino, 55 anos, procurou atendimento odontológico e foi diagnosticado com periodontite generalizada em estágio avançado e crescimento gengival associado ao uso de anlodipina, um bloqueador dos canais de cálcio de ação prolongada. O tratamento consistiu em interrupção da anlodipina, sessões de instruções de higiene bucal e terapia periodontal básica. Posteriormente, foi realizada terapia periodontal convencional, com raspagem e alisamento radicular dos quatro hemiarcos, seguida de cirurgia periodontal a retalho e gengivectomia. Considerando os sítios periodontais com profundidade de bolsa à sondagem (PBS) > 4mm no início do tratamento, a média de PBS foi reduzida (início: 5,94 ± 1,80; final: 2,76 ± 1,38), bem como a média do nível clínico de inserção (início: 5,55 ± 1,51; final: 4,52 ± 1,47). A doença periodontal foi controlada e não houve recorrência do crescimento gengival após 18 meses de acompanhamento. Conclusão: O tratamento odontológico deste paciente com DRC e envolvimento periodontal incluiu a interrupção da anlodipina, terapia periodontal básica e avançada e gengivectomia. A higiene bucal adequada pode ajudar a prevenir a recorrência do crescimento gengival excessivo e a manutenção de um estado periodontal saudável.

The Novel Coronavirus and Prevention Goes Viral

Assim como os vírus respiratórios, o novo coronavírus, o SARS-CoV-2, é trasmitido principalmente pelo contato com gotículas respirátorias de indivíduos com COVID-19. Pessoas de todas as idades podem ser infectadas por ele. O risco de apresentar doença mais grave é maior naquelas com mais de 60 anos e com doenças não transmissíveis pré-existentes. Dentre essas, estão a doença cardiovascular, a doença respiratória obstrutiva crônica (DPOC), o diabetes mellitus, o câncer. Outro fator de risco que torna as pessoas mais vulneráveis a se tornarem gravemente doentes com COVID-19 é o tabagismo. O ato de fumar implica em dedos (e possivelmente cigarros contaminados) em contato com os lábios, o que aumenta a possibilidade de transmissão do vírus de mão para a boca.

Osteoporosis, tooth loss and functional dentition in elderly women: a cross-sectional study

Objectives: The objective of this study was to investigate whether osteoporosis is an indicator of missing teeth and lack of functional dentition in elderly women. Methods: A cross-sectional study involving women aged more than 60 years was performed at the Brazilian's Navy Dental Center (Odontoclínica Central da Marinha) , Rio de Janeiro, Brazil. Demographic data and general health status information of the group were obtained through individual interviews. In addition, the number of natural teeth was recorded in oral examination. Women presenting at least one tooth were divided in groups presenting or not osteoporosis. The number of natural teeth was compared between groups, with adjustment for smoking and diabetes mellitus. The association between functional dentition and osteoporosis was evaluated using odds ratios (ORs) and their respective 95% confidence intervals. Results: Data on oral examination were available for 256 of the 360 elderly women registered in the database. The groups were composed by 55 women with osteoporosis and 201 not presenting osteoporosis. The prevalence of chronic diseases and smoking, was similar between groups. The mean number of teeth for osteoporotic women was significantly lower than in those without this disease (14,69 ± 7,69 versus 18,19 ± 7,20, p= 0.002), remaining significant after adjustment for potential confounders. Women without osteoporosis exhibited greater chance to present functional dentition than those with osteoporosis (OR = 2.10, 95% CI [1.21 to 3.66], p =0.006). Conclusion: Osteoporosis was an indicator for tooth loss and lack of functional dentition in the studied population of elderly women.

Objetivos: O objetivo deste estudo foi investigar se a osteoporose é um indicador de perda dentária e de falta de dentição funcional em idosas. Métodos: Um estudo transversal envolvendo mulheres com mais de 60 anos foi realizado na Odontoclínica Central da Marinha, Rio de Janeiro, Brasil. Dados demográficos e médicos foram obtidos através de entrevistas individuais. Os dentes naturais foram contados no exame oral. Mulheres com um ou mais dentes foram divididas em dois grupos: com e sem osteoporose. O número de dentes naturais foi comparado entre os grupos, com controle para tabagismo e diabetes mellitus. A associação entre a dentição funcional e a osteoporose foi avaliada por meio de odds ratios (OR) e seus respectivos intervalos de confiança de 95%. Resultados: Dentre 360 idosas cadastradas no banco de dados, 256 tinham registro de exame oral. Os grupos foram compostos por 55 mulheres com osteoporose e 201, sem. A prevalência de doenças crônicas e tabagismo foi semelhante entre os grupos. O número médio de dentes para mulheres com osteoporose foi significativamente menor do que as que não tinham a doença (14,69 ± 7,69 versus 18,19 ± 7,20, p = 0,002), permanecendo significativo após o ajuste para possíveis fatores de confundimento. Mulheres sem osteoporose tiveram maior chance de apresentar dentição funcional do que as outras (OR = 2,10, IC 95% [1,21-3,66], p = 0,006). Conclusão: A osteoporose foi um indicador de perda dentária e de ausência de dentição funcional na população estudada.

Comparação entre parâmetros clínicos periodontais de idosas com e sem osteoporose / A comparison between clinical periodontal parameters of elderly women with and without osteoporosis

A associação entre a osteoporose e a doença periodontal ainda não é evidente e os resultados obtidos em estudos sobre o tema se mostraram controversos. O objetivo desse estudo foi comparar os parâmetros clínicos periodontais de idosas com e sem osteoporose, a fim de testar a hipótese de que existe uma maior prevalência e gravidade de periodontite crônica nas mulheres com osteoporose. Além disso, um segundo objetivo foi verificar se a medicação para osteoporose e o status sérico da vitamina D poderiam influenciar nesses resultados. Neste estudo transversal, 134 idosas, 48 com densidade mineral óssea (DMO) normal e 86 com osteoporose, foram selecionadas dentre 1266 indivíduos que realizaram exame de densitometria óssea da coluna lombar e fêmur proximal usando absorciometria de Raios-X de dupla energia. Foram coletados dados sócio-demográficos e realizada avaliação periodontal completa. Níveis séricos de 25 (OH) vitamina D foram mensurados por quimioluminescência. Mulheres com osteoporose apresentaram maior frequência de níveis de inserção clínica ≥ 6mm (p = 0.003) e recessão gengival ≥ 3mm (p = 0.002) do que mulheres com DMO normal, além de terem tido mais que o dobro de chance de apresentar periodontite crônica avançada (odds ratio (OR) = 2.49, 95% CI [1.14 to 5.43], p =0.020). No grupo da osteoporose, as que não eram tratadas para esta condição apresentaram maior chance de ter periodontite crônica (OR= 3,16, 95% CI [1,28-7,82], p = 0,011) do que as que usavam bisfosfonatos (OR= 2,04, 95% CI [0,85-4,89], p = 0,109). Dentre as idosas que apresentavam baixos níveis de vitamina D, aquelas com osteoporose apresentaram maior chance de apresentar periodontite avançada do que aqueles com DMO normal (OR = 3.34, 95% CI [1.12 a 10.04], p =0.027), mas a associação entre os níveis de vitamina D e osteoporose não foi estatisticamente significativa após o ajuste (p = 0,198). Em suma, idosas com osteoporose tiveram mais que o dobro de chance de apresentar periodontite crônica avançada do que idosas com DMO normal. Os efeitos negativos da osteoporose na condição periodontal foram minimizados com uso de medicação para tratamento da osteoporose. (AU)

The association between osteoporosis and periodontal disease is still with conflicting results being obtained for the corresponding studies conducted so far. The objective of this study was to compare the clinical periodontal parameters of elderly women with osteoporosis or not, in order to test the hypothesis that there is an increased prevalence and severity of chronic periodontitis in osteoporotic ones. In addition, a second objective was to investigate whether medication for osteoporosis and serum vitamin D status could affect these results. In this cross-sectional study, 134 elderly women, 48 with normal bone mineral density (BMD) and 86 with osteoporosis, were selected among 1266 subjects evaluated for lumbar spine and proximal femur BMD using dual energy x-ray absorptiometry. Socio-demographic characteristics and complete periodontal examination were recorded, and serum 25- hydroxyvitamin D levels were measured by chemiluminescence. Women with osteoporosis presented a higher frequency of sites with clinical attachment level ≥ 6 mm (p = 0.003) and gingival recession ≥3mm (p = 0.002) than those with normal BMD, and were more than twice as likely to present severe periodontitis (odds ratio (OR) = 2.49, 95% CI [1.14 to 5.43], p =0.020). Osteoporotic women who were not treated for the condition had more chance to present severe periodontitis (OR = 3.16, 95% CI [1.28 to 7.82], p =0.011) than those who did use bisphosphonates (OR= 2.04, 95% CI [0.85 to 4.89], p =0.109). Among the participants who presented low levels of vitamin D, those with osteoporosis exhibited greater chance to present severe periodontitis than those with normal BMD (OR = 3.34, 95% CI [1.12 to 10.04], p =0.027), but the association between vitamin D levels and osteoporosis was not statistically significant after adjustment (p = 0.198). In conclusion, elderly women with osteoporosis had a greater chance to present periodontitis, with higher severity than those with normal BMD. The negative effects of osteoporosis on periodontal status were minimized with medication for treatment of osteoporosis. (AU)